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Laser Holographic Biosensing Mechanism Using Porous Protein Laden Hydrogel
Start Date 8/1/2008
End Date 7/31/2009
Primary Partner: Syracuse University
Primary Contact: Luk, Yan-Yeung - Assistant Professor
Other Project Contacts:
Ren, Dacheng - Co-Principal Investigator
Sponslor, Michael - Co-Principal Investigator
Project Type: CARTI III
Technical Description:
With a continuing increase in our population, and ever increasing demand for fresh water, there is a critical need to monitor drinking water quality. Throughout history, numerous incidences of epidemics of disease and death have been attributed to microorganism contamination of drinking water. Even in modern times, with drinking water sanitized by chlorination or other means, occasional outbreaks occur. In fact, there is evidence that bacterial contamination of water supplies is actually increasing throughout the world.
There is currently a need for a real-time monitoring system for the presence of bacterial contamination of drinking water supplies. A few alternative methods for monitoring water quality have been reported in recent years but these methods still mainly use batch sampling techniques and may involve complex procedures, expensive equipment or long response times. The health (and lives) of people may be put at risk due to the length of time involved in testing water for contamination. This problem is especially prevalent in developing nations where inadequate monitoring and sanitation of drinking water is quite common.
Expected Outcomes:
Herein we report our work to develop detection systems for waterborne pathogens based on hydrogels decorated with antibodies specific for the targeted pollutants.
Accomplishments:
This project established a new mechanism for detecting aqueous borne toxins by integrating the antigen-triggered mechanical changes with the diffraction of a passing through laser. While promising, we are optimizing the sensor to achieve high sensitivity and fast response time.
Benefits:
Rapid and/or real-time detection of water borne contaminants will reduce health risks currently present due to the length of time needed for standard water testing procedures.
For more information: http://www-che.syr.edu/faculty/luk.html
Peer-reviewed journal publications:
Induced Folding by Chiral Non-Planar Aromatics Sri Kamesh Narasimhan, Deborah J. Kerwood, Lei Wu, Jun Li, Rosina Lombardi, Teresa B. Freedman* and Yan-Yeung Luk* J. Org. Chem., 2009, 74(18), 7023-7033.
Selective Immobilization of Peptides Exclusively via N-Terminus Cysteines by Water-Driven Reactions on Surfaces Preeti Sejwal, Sri Kamesh Narasimhan, Deepali Prashar, Debjyoti Bandyopadhyay and Yan-Yeung Luk* J. Org. Chem., 2009, 74(17), 6843-6846.
Non-Amphiphilic Assembly in Water: Polymorphic Nature, Thread Structure and Thermodynamic Incompatibility Lei Wu, Jyotsana Lal, Karen A. Simon, Erik A. Burton and Yan-Yeung Luk* J. Am. Chem. Soc., 2009, 131, 7430-7443.
Prolonged Control of Patterned Biofilm Formation by Bio-inert Surface Chemistry Shuyu Hou, Erik A. Burton, Ricky Lei Wu, Yan-Yeung Luk* and Dacheng Ren* Chem. Commun., 2009, 10, 1207-1209.
Molecular Gradients of Bio-inertness Reveal Mechanistic Difference between Mammalian Cell Adhesion and Bacterial Biofilm Formation Erik A. Burton, Karen A. Simon, Shuyu Hou, Dacheng Ren* and Yan-Yeung Luk* Langmuir, 2009, 25, 1547-1553.
Patent applications:
Yan-Yeung Luk, Karen A. Simon, Erik A. Burton "Real time biosensor based on functional hydrogel materials” in preparation.
Research results indicating a positive detection of the antigen
Image Credit: Yan-Yeung Luk, Syracuse University
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